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an elderly woman getting medical care

For the fifth consecutive year, NewYork Quality Care, the accountable care organization (ACO) of NewYork-Presbyterian, Columbia University Irving Medical Center and Weill Cornell Medicine, has earned shared savings in the Centers for Medicare & Medicaid Services (CMS) Medicare Shared Savings Program. In 2021, NewYork Quality Care saved Medicare $26,335,014 while providing high quality care for more than 35...

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colonies of a fungus

The presence of some fungal species in tumors predicts—and may even help drive—worse cancer outcomes, according to a study from Weill Cornell Medicine and Duke University researchers.

The study, which appears Sept. 29 in Cell, provides a scientific framework to develop tests that delineate specific fungal species in tumors that are relevant for prediction of cancer progression and therapy. The results also point to...

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a doctor showing an older male patient his medical results

A new screening tool for electronic medical records accurately identifies patients who are at high risk of having or developing progressive scarring of the lungs, a condition called idiopathic pulmonary fibrosis, according to investigators from Weill Cornell Medicine, NewYork-Presbyterian, the University of Chicago, Brigham and Women’s Hospital and Mayo Clinic.

Idiopathic pulmonary fibrosis (IPF) is usually fatal, in part because it tends to be diagnosed late in its course, when...

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diagram of loss of nuclear soluble adenylyl cyclase in melanoma cells

By analyzing key enzymes in a new way, an international team led by researchers at Weill Cornell Medicine has discovered how a well-known signaling molecule can either stimulate or suppress tumor growth depending on where it’s produced. The work, published Sept. 27 in Cell Reports, reveals a new aspect of tumor cell biology, and points to a promising strategy for treating many types of...

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illustration of DNA

An advanced software tool for analyzing DNA sequences from tumor samples has uncovered likely new cancer-driving genes, in a study led by Weill Cornell Medicine researchers.

In the study, published Sept. 26 in Nature Communications, the researchers designed the software, known as CSVDriver, to map and analyze the locations of large mutations, known as structural variants (SVs), in tumor DNA datasets. They then applied the...

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illustration of blood cells

A common, spontaneous mutation in blood stem cells, which has been linked to higher risks of blood cancer and cardiovascular disease, may promote these diseases by altering the stem cells’ programming of gene activity and the mix of blood cells they produce, according to a study co-led by investigators at Weill Cornell Medicine, NewYork-Presbyterian, the New York Genome Center...

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image of a person with parkinson's disease at the doctor

Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson’s disease through a cellular waste-ejection process, suggests a new study led by Weill Cornell Medicine researchers.

During the process, called lysosomal exocytosis, neurons eject protein waste they cannot break down and recycle. The discovery, published Aug. 22 in Nature Communications, could resolve one of the mysteries...

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Weill Cornell Medicine investigators have identified definitive biological links between African ancestry and disease processes that affect an aggressive cancer type called triple-negative breast cancer (TNBC). Their analysis of TNBC tumors from a diverse patient population yielded a large set of genes whose expression differed in patients with African ancestry compared with patients with European ancestry.

In the study, published Sept. 19 in Cancer Discovery, a journal of the American...

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memory loss concept

A collaboration between Weill Cornell Medicine scientists and other leaders in Alzheimer’s disease research has revealed widespread metabolic changes in the brains of individuals with Alzheimer’s disease. The findings could lead to the development of new treatments aimed at ameliorating the metabolic effects of the disease.

For the study, published July 13 in Alzheimer’s and Dementia, the investigators...

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two men walk together down a dirt path

An easy-to-use device for infant circumcision has proved to be safe in an international randomized controlled clinical trial led by Weill Cornell Medicine physician-scientists. The results suggest that the device could boost efforts to increase circumcision rates and prevent HIV in low-resource settings where early infant circumcision is not widespread. 

The trial, whose results were...

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Tampa FL (Sept. 13, 2022) – Artificial intelligence may soon help doctors diagnose and treat diseases, including cancer and depression, based on the sound of a patient’s voice, as 12 leading research institutions launch a landmark National Institutes of Health-funded academic project that may establish voice as a biomarker used in clinical care.

The University of South Florida in Tampa, FL, is the lead institution on the project in collaboration with...

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NEW YORK (Sept. 9, 2022)—Weill Cornell Medicine was awarded a $61.9 million grant from the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS) to continue funding its Clinical and Translational Science Center (CTSC) until 2027. It is the largest federal grant ever awarded to Weill Cornell Medicine and the fourth consecutive time this initiative has been funded by the NIH, representing...

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healthy mouse intestine

Immune cells called group 3 innate lymphoid cells (ILC3s) play an essential role in establishing tolerance to symbiotic microbes that dwell in the human gastrointestinal tract, according to a study led by researchers at Weill Cornell Medicine.

The discovery, reported Sept. 7 in Nature, illuminates an important aspect of gut health and mucosal immunity—one that may hold the key to better treatments for inflammatory bowel...

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A scientist in a lab doing research. Credit: Shutterstock

Weill Cornell Medicine has been awarded a five-year, $5 million grant from the National Institutes of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health to establish a new multi-institutional center for tuberculosis (TB) research and training the next generation of TB investigators. The New York Tri-Institutional TB Research Advancement Center (TRAC) will provide seed-funding to both early-career and established researchers new to TB science, and extend outreach...

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Dr. Gunisha Kaur, an assistant professor of anesthesiology at Weill Cornell Medicine and medical director of the Weill Cornell Center for Human Rights, has been selected as an Emerging Leaders in Health and Medicine (ELHM) Scholar by the National Academy of Medicine.

Dr. Kaur, a respected human rights researcher, was one of 10 ELHM Scholars chosen this year. Established in 2016, the ELHM program annually selects early-...

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progressively zoomed in image of thymic cancer

A new preclinical model for thymic cancer developed by Weill Cornell Medicine investigators has revealed insights into how a common mutation found in thymic epithelial tumors sparks their formation. The model may help speed the development of targeted therapies for cancer of the thymus, a gland that makes immune cells that help protect the body from infections.

In a study published Aug. 29 in the Journal of...

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younger woman with hand on shoulder of older woman

A new study from Weill Cornell Medicine investigators shows that cultural values and social support may influence a caregiver’s burden, self-efficacy and depressive symptoms. These findings suggest interventions aimed at buffering the negative effects of care-related stress should reinforce the importance of social connections. 

In a study reported in the July 2022 issue of the Journals...

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illustration of human liver anatomy

When fat accumulates in the liver, the immune system may assault the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that trips these defenses, a discovery that helps to explain the dynamics underlying liver damage that can accompany type 2 diabetes and obesity. 

In a study published Aug. 19 in Science Immunology, researchers mimicked these human metabolic diseases by genetically...

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HIV

Vaccination with a SARS-CoV-2 mRNA vaccine revealed HIV hiding in immune cells in blood from people with HIV, according to lab research led by Weill Cornell Medicine investigators. The findings, published Aug. 19 in Nature Communications, identify new tools for evaluating treatment approaches in development aimed at curing HIV.

“There is prior knowledge of the flu vaccine, for example, waking up HIV and exposing it to the...

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illustration of a virus

A new preclinical study by Weill Cornell Medicine investigators found that certain bacteria in the gut may reduce susceptibility to SARS-CoV-2 infection, improve the immune response and prevent blood clots that can occur in severe COVID-19 illness. The study, published Aug. 1 in Gut Microbes, suggests that dietary choices may also have the potential to enhance efforts to combat COVID-19 and its complications in...

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