News & Events

Dr. Samie Jaffrey, the Greenberg-Starr Professor in the Department of Pharmacology at Weill Cornell Medicine, has received a five-year, $5.5 million NIH Director’s Transformative Research Award for the comprehensive study of how messenger RNAs are regulated in cells by small molecules called metabolites.

The NIH Director’s Transformative Research Awards, part of the Common Fund’s High-Risk, High-...

Dr. Olivier Elemento, the director of the Englander Institute for Precision Medicine at Weill Cornell Medicine, has been awarded an NIH Director's Pioneer Award to build an artificial intelligence (AI) tool to accelerate cancer research, starting with lung cancer.

Part of the Common Fund’s High-Risk, High-Reward Research program, the award supports scientists with outstanding records of creativity to develop pioneering approaches to...

Researchers have discovered a new cell type that may help regulate blood vessel growth in the heart during development and in response to injury, according to a study from Weill Cornell Medicine. Working with zebrafish, they found that the new cell type helps stabilize the vascular network that supplies oxygen to growing cardiac muscle.

The findings, published Aug. 20 in Nature Communications, could...

Surgery to remove lymph nodes in the neck may interfere with cerebrospinal fluid (CSF) drainage from the brain, contributing to cognitive impairment, according to new multicenter research led by Weill Cornell Medicine scientists.

The paper, published Sept. 29 in Neuron, found that patients with head and neck cancer undergoing cervical lymphadenectomy, a procedure to remove nearby lymph nodes to reduce...

Weill Cornell Medicine investigators have determined the mechanism by which a molecule within cells can help tune the light sensitivity of the eyes. The study identified the molecule’s binding site on a protein in retinal cells, which should enable the development of drugs that target this site to treat related eye diseases.

Weill Cornell Medicine has received major new funding to support collaborative research spanning clinical trials, precision medicine and drug target discovery with the potential to improve outcomes for patients with challenging cancers.

Dr. Effie Apostolou

Associate Professor of Molecular Biology in Medicine and member of the Meyer Cancer Center and of the...

Chronic stress may contribute to the pain and urinary symptoms experienced by people with interstitial cystitis/bladder pain syndrome (IC/BPS) by triggering changes in the bladder and nervous system, according to a preclinical study by Weill Cornell Medicine investigators. IC/BPS, a chronic condition affecting millions, causes pain, pressure or discomfort in the bladder and pelvic area, often accompanied by an urgent or frequent need to urinate.

Researchers at Weill Cornell Medicine have received a $17.4 million, five-year grant from the National Institute of Allergy and Infectious Diseases to discover new approaches to shorten tuberculosis (TB) treatment, potentially making it easier for patients to complete therapy. The researchers aim to shift TB drug development toward creating new drugs from the start to work in the combinations needed to cure TB. 

Though a course of antibiotics, when completed, can cure the infectious...

The biologic drug interferon-alpha can benefit patients with blood cancers called myeloproliferative neoplasms by forcing mutant blood stem cells to become shorter-lived white blood cells, according to a study by Weill Cornell Medicine investigators. Because the broad activity of interferon-alpha can induce significant side effects, developing new focused strategies based on these mechanistic findings could meet an important need in cancer therapy.

Metabotropic glutamate receptors, which are important but difficult drug targets, interact in surprisingly varied ways with their principal regulatory proteins, according to two new studies led by Weill Cornell Medicine investigators. The findings represent a big step forward in understanding these receptors and how they can be targeted effectively to potentially treat conditions such as epilepsy, depression, and anxiety disorders.

...

Weill Cornell Medicine and Rutgers Health in New Brunswick have received a four-year, $3 million grant from the National Institute of Mental Health (NIMH) to build the infrastructure and resources that will accelerate discoveries about HIV-associated brain injury. The New York-New Jersey Center for Actionable NeuroHIV Biomarkers (NYJ-CAN-BIO) will provide the expertise, training and latest technologies needed to understand how HIV impacts the brain. This research center could uncover...

Contrary to some predictions, the use of artificial intelligence (AI) agents could lead to more, not fewer, health care professionals working in the United States, according to a new article by a physician and health policy researcher at Weill Cornell Medicine who surveyed economic theory and the history of technology in health care.

Obesity caused by disrupted stress-hormone rhythms is metabolically very different from obesity caused by a high-fat diet, according to a new preclinical study by Weill Cornell Medicine investigators. The researchers found in mice that glucocorticoid-rhythm disruption concentrates insulin resistance in skeletal muscle while preserving key insulin responses in fat tissue and liver. This allows fat tissue to continue storing lipids, while the liver remains largely protected from the fat...

Dr. Geraldine McGinty, an esteemed academic healthcare leader and radiologist, has been appointed executive vice dean of Weill Cornell Medicine, effective Sept. 8.

In her new role, Dr. McGinty will serve as a vital strategic advisor to Dean Robert A. Harrington, exercise delegated authority on key matters and represent the institution internally and externally on topics central to Weill Cornell’s academic, clinical and professional life.

“In my nearly three years at Weill Cornell...

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the stem cells—unspecialized cells that can develop into specific cell types—that give rise to the body’s tendons and ligaments, the tissues connecting muscles and bones. They also found that when these stem cells become hyperactive in the lower spine, they contribute to lumbar spinal stenosis. This condition, which impacts an estimated 103 million people worldwide, involves enlarged ligaments that can...

Dr. Zachary Grinspan, associate professor of pediatrics and director of the Pediatric Epilepsy Program at Weill Cornell Medicine, has been awarded a four-year, $1.6 million CDC grant to undertake wide-reaching research aiming to produce a new, more detailed picture of childhood epilepsy.

...

A commonly used systemic antifungal medication may help reduce symptoms in a subset of patients with inflammatory bowel disease (IBD) by restoring a healthier gut microbiome, according to a preliminary study by Weill Cornell Medicine investigators. 

A team of Weill Cornell Medicine investigators has developed a computer model that will help scientists more efficiently develop protein-destroying therapies, a newer type of treatment that is particularly promising for cancer. The study was published July 13 in Nature Communications.

Most drugs use a small molecule to render disease-causing proteins harmless, but protein-degrader therapies aim to destroy the...

Tuberculosis bacteria released into the air from infected individuals dry out to form infectious particles that are second only to measles in contagiousness. Weill Cornell Medicine investigators have discovered specific mechanisms that enable the bacteria not only to survive drying but also to generate mutations linked to antibiotic resistance. This suggests that transmission involves more than the passive movement of bacteria between people and may be a period during which the pathogen...

Weill Cornell Medicine investigators have developed a set of molecular tools to regulate the activity of specific genes in one of the most common classes of intestinal bacteria. The ability to genetically manipulate these microbes could lead to a better understanding of the role they play in human physiology and diseases.

In healthy individuals, species of Clostridia comprise half of the bacteria found in the gut. Many produce metabolites that are likely beneficial for human health and...