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a saline bag

Treatment with a ready-made preparation of human immune cells helps prevent infections in people whose immune systems are temporarily weakened by leukemia treatment, according to a phase 2 clinical trial led by researchers at Weill Cornell Medicine and NewYork-Presbyterian. Infections are a significant problem in patients undergoing chemotherapy for cancer.

The cell preparation, known as romyelocel-L, consists of immature, human-derived immune cells that work to replenish white blood...

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multicolor dots representing different cell types

The genetic changes that underlie an especially lethal type of prostate cancer have been revealed in a new study by investigators at Weill Cornell Medicine. Learning more about what causes this type of cancer, called neuroendocrine prostate cancer (NEPC), could lead to new approaches for treating it.

Most early-stage prostate cancers require male hormones (androgens) like testosterone to grow. However, as they advance, they may evolve into castration-resistant prostate cancer (CRPC), a...

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molecular image showing molecule engaging membrane protein

The structure and function of an important protein that transports essential omega-3 fatty acid molecules from the bloodstream into the brain has been determined by a team led by scientists at Columbia University Vagelos College of Physicians and Surgeons, Weill Cornell Medicine, and Duke-NUS Medical School. The findings illuminate a crucial aspect of brain health and development, and open the...

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image of crystal structure and atomic force microscopy results

image of atomic force microscopy and crystallography results

Click on the image to view a video about the paper.

Scientists at Weill Cornell Medicine have...

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doctor holding patients hand

Two gene variants found in African American women may explain why they are more likely to be diagnosed with triple negative breast cancer (TNBC) than white women of European ancestry, according to Weill Cornell Medicine and NewYork-Presbyterian investigators. The study findings may have implications for developing better risk assessment tools for TNBC in African American women and for understanding why they have poorer TNBC outcomes.

In a...

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four images of brown fat cells

A new understanding of the interaction of two proteins and their role in fat burning and storage may one day have implications for the treatment of obesity and associated diseases such as diabetes and cancer, according to Weill Cornell Medicine investigators.

Their preclinical research, published May 17 in Nature Communications, explores how the proteins p62 and NBR1 influence thermogenesis, or fat burning to produce body...

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a large T cell

A team led by researchers at Weill Cornell Medicine and Children’s National Hospital has developed a unique pre-clinical model that enables the study of long-term HIV infection, and the testing of new therapies aimed at curing the disease.

Ordinary mice cannot be infected with HIV, so previous HIV mouse models have used mice that carry human stem cells or CD4 T cells, a type of immune cell that can be infected with HIV. But these models tend to have limited utility because the human...

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drawing of lungs

Adding antibiotics to usual care does not improve outcomes for people with the lung disease idiopathic pulmonary fibrosis (IPF), according to the findings from a multi-center, phase 3 clinical trial sponsored by Weill Cornell Medicine.

Importantly, the investigators note that although the trial had negative findings, the novel way it was designed and conducted could pave the way for future studies that are less expensive and easier to conduct. The...

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3d rendered illustration of excess white blood cells

Scientists have made major advances in understanding and developing treatments for many cancers by identifying genetic mutations that drive the disease. Now a team led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and the New York Genome Center (NYGC) has developed a machine learning technique for detecting other modifications to DNA that have a similar effect.

The...

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students sitting together on campus

Weill Cornell Medicine’s commitment to diversity and inclusion spans all parts of its mission, but starts with education. From its pipeline programs to an increasingly engaged student population, the institution strives to build an inclusive community where the next generation of diverse physicians and scientists are equipped to address issues of health equity and advocate for patients from all backgrounds.

A Pipeline to Medicine and Community Care

Weill Cornell Medicine’s vast...

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a woman looking out into a distance

Patients with gynecologic cancers who have Medicaid coverage are more likely to feel increased financial distress, anxiety about their cancer and increased general anxiety during the pandemic if their annual income is less than $40,000, according to a new study from Weill Cornell Medicine investigators.

The study’s findings, published April 26 in Cancer, suggest that physicians should ask these women more about the challenges they face in completing their treatments and link them with...

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cells stained to show damage from COVID-19

The heart damage seen in many severely ill COVID-19 patients results in part from infection-activated immune cells called macrophages, which infiltrate the heart and secrete cell-damaging chemicals, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian, Icahn School of Medicine at Mount Sinai and Columbia University Irving Medical Center. The research identifies new...

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illustration of red blood cells

Dr. Jeffrey Laurence, a professor of medicine in the Division of Hematology and Medical Oncology at Weill Cornell Medicine and a hematology and oncology specialist at NewYork-Presbyterian/Weill Cornell Medical Center, co-authored a now-widely cited...

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brain showing flurorescent prefrontal cortex cells

To enable animals to shift their attention in response to changing circumstances, the prefrontal cortex of the brain helps keep track of which types of stimuli have recently been most relevant, suggests a preclinical study by Weill Cornell Medicine and NewYork-Presbyterian investigators. This discovery could lead to new treatments to help restore cognitive flexibility.

“Animals and people make split-second decisions about what to do in changing circumstances and what to pay attention...

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T cell lymphocyte with receptors

Radiation therapy appears to increase or upregulate the expression of genes with mutations that induce an immune response to malignant cells, according to preclinical research by Weill Cornell Medicine and NewYork-Presbyterian investigators. The findings suggest that radiation treatment directed to tumors may help to improve a form of immunotherapy that currently has limited effectiveness.

The new research, published Jan. 21 in The...

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cells under a microscope

Molecular "bookmarks," which allow cells to retain their characteristics during cell division, ensure fast reactivation of critical cell identity genes after cell division, according to investigators at Weill Cornell Medicine. The new work helps illuminate a process that has puzzled biologists for decades and suggests new strategies for modulating cell fate both for stem cell therapy and cancer treatment.

When cells undergo division, or mitosis, they temporarily shut down their normal...

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a woman smiling for a photo, holding a sign showing where she matched for Match Day 2021

Video of A Virtual Celebration for Match Day 2021 at Weill Cornell Medicine

For Rana Khan, earning a residency in obstetrics and gynecology at NewYork-Presbyterian/Weill Cornell Medical Center was more than just realizing a milestone in her medical education. Match Day was the culmination of a personal journey that transported Khan from medical student to cancer patient to...

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an illustraion of a heart graph made out of sugar

Excess sugar in the blood, the central feature of diabetes, can react with immune proteins to cause myriad changes in the immune system, including inflammatory changes that promote atherosclerosis, according to a new study from scientists at Weill Cornell Medicine and University of Massachusetts Medical School.

The study, published March 15 in the journal Immunity, advances the field of diabetes research by...

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illustration of cells in the body

A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain.

Isoform variation is a process that extends the versatility of...

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Composite photo of two scientists

The first and largest genetic association study in the Middle East revealed genetic variations that are specific to the Qatari population, a group of researchers at Qatar Foundation reported Feb. 23 in Nature Communications.

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