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small molecule checkpoint inhibitor

The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers.

Checkpoint inhibitors are a type of immunotherapy that treats cancer by releasing the brakes on immune cells, so they are unleashed to attack cancer cells. Currently, all approved checkpoint inhibitors are large, lab-made proteins called monoclonal antibodies which must be infused...

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Portable prism PET scanner

Weill Cornell Medicine researchers have received a $6.2 million, five-year grant from the National Institute on Aging, part of the National Institutes of Health, to build a portable, high-resolution Positron Emission Tomography (PET) scanner that can detect the earliest stages of Alzheimer’s disease.

Unlike current models, this PET scanner will be upright, so a patient can sit in a chair that travels with the unit, significantly improving...

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Dr. Chani Traube

Dr. Chani Traube, the Gerald M. Loughlin, MD Professor of Pediatrics at Weill Cornell Medicine, has been awarded a $3.4 million grant, with the possibility of extending to a total of $17 million over five years, from the National Institutes of Health, for a large-scale clinical trial called Optimizing Pain Treatment in Children on Mechanical ventilation (OPTICOM).

OPTICOM, funded by the Eunice Kennedy Shriver...

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gloved hand holding lab tube

Three teams led by Weill Cornell Medicine scientists have received awards from the Starr Cancer Consortium in its 17th and final annual grant competition. The grants will fund research on the deep mechanisms of common cancers and related treatment strategies.

The Starr Cancer Consortium, established in 2006 with generous support from The Starr Foundation, includes The...

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A group of people evaluate a patient in an MRI machine

George Vann once worked the beat as law enforcement for MTA Bridges and Tunnels with a side gig as a plumber — until an uncontrollable shake in both hands took those jobs away from him.

The tremors started around 2010. Vann, now 74, from Jamaica, Queens, struggled to grasp his firearm without shaking. He couldn’t hold steady a wand to test gas meters. He couldn’t carry a cup of coffee or use a spoon. To eat, Vann had to bring food right to his mouth. He never ate out at restaurants....

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T cells able to pick up lipds

Weill Cornell Medicine researchers have discovered a mechanism that ovarian tumors use to cripple immune cells and impede their attack—blocking the energy supply T cells depend on. The study, published Oct. 23 in Nature, points toward a promising new immunotherapy approach for ovarian cancer, which is notoriously aggressive and hard to treat.

A significant obstacle in treating ovarian cancer is the...

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metastasizing melanoma cells

Investigators from Weill Cornell Medicine have discovered a defense mechanism that protects skin cancer cells from oxidative stress and helps them spread. The findings suggest a new drug target that could lead to therapies for deadly metastatic skin cancer.

When cancer cells colonize vital organs, they enter hostile territory, making it difficult to metastasize. Melanoma cells, for instance, experience high levels of oxidative stress in the bloodstream and at distant sites that kill...

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microscope images of blastocyst stage embryos

A new artificial intelligence-based system can accurately assess the chromosomal status of in vitro-fertilized (IVF) embryos using only time-lapse video images of the embryos and maternal age, according to a study from investigators at Weill Cornell Medicine.

The new system, called "BELA,” and described in a paper published Sept. 5 in Nature Communications, is the team’s latest AI-based platform for assessing whether an...

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Two men take a picture together in an auditorium

Health care in the United States is at a crossroads, said U.S. Food and Drug Administration Commissioner Dr. Robert M. Califf, in large part due to a confluence of post-COVID disinformation, rising cardiovascular mortality rates, a heavier burden of chronic diseases and decreased life expectancy.

New York state however stands out as a bright spot. The state’s success is one of the reasons that brought Dr. Califf...

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Multiplex immunofluorescence image of human hepatocellular carcinoma tissue

It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study by Weill Cornell Medicine investigators.

The study, published Oct. 17 in Molecular Cell, provides new insights into a pair of proteins, called p62 and NBR1, and their opposing functions in regulating the interferon response in...

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Long Covid

The first randomized, placebo-controlled clinical trial evaluating the impact of therapeutic monoclonal antibodies on the risk of developing long COVID was led by researchers at Weill Cornell Medicine. The study, published Sept. 1 in eClinicalMedicine, details an international, multicenter phase 2/3 clinical trial that found a combination of amubarvimab and romlusevimab did not reduce the...

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Taming Weed

Graphic of a vape device with smoke forming a triangle around it to mimic a caution sign

While most states have legalized or decriminalized marijuana, regulation is limited, and products range in form from leaves to vapes to edibles and can carry far higher concentrations of psychoactive ingredients than were typical decades ago. How can medicine and public health best address these largely unregulated, readily available and potentially harmful products? 

...

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microscopic images of cells with proteins tagged in red and green

Immune cells called monocytes produce a key inflammatory protein called interleukin-1 beta (IL-1β) through an unconventional pathway in patients with systemic lupus erythematosus, commonly referred to as lupus, according to a new study by Weill Cornell Medicine investigators.

The findings, published Oct. 7 in Immunity, could lead to new treatments targeting IL-1β to better manage inflammation in patients who don...

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Dr. Ali Jalali

Video of NIH New Innovator Award Recipient - Dr. Ali Jalali

Dr. Ali Jalali, an assistant professor of population health sciences at Weill Cornell Medicine, was awarded the prestigious National Institutes of Health (NIH) Director’s New Innovator Award through its Helping to End Addiction...

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Selective transduction of D2-type iSPN with RNA in situ hybridization. Colocalization of D2-type (green) iSPN with mCherry (red).

A new technology enables the control of specific brain circuits non-invasively with magnetic fields, according to a preclinical study from researchers at Weill Cornell Medicine, The Rockefeller University and the Icahn School of Medicine at Mount Sinai. The technology holds promise as a powerful tool for studying the brain and as the basis for future neurological and...

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Artistic rendition of extrachromosomal DNA and chromosomes

How bladder cancer originates and progresses has been illuminated as never before in a study led by researchers at Weill Cornell Medicine and the New York Genome Center. The researchers found that antiviral enzymes that mutate the DNA of normal and cancer cells are key promoters of early bladder cancer development, and that standard chemotherapy is also a potent source of mutations. The researchers also discovered that overactive genes within abnormal...

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Dr. Randy Longman

Dr. Randy Longman, director of the Jill Roberts Center for Inflammatory Bowel Disease and an associate professor of medicine at Weill Cornell Medicine, and colleagues have received the NIH Director’s...

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patient portal privacy

The possibility of parental disclosure through online patient portals led older adolescents to hesitate in sharing complete health information with doctors, putting them at risk of missed diagnoses and treatments, a new study by Weill Cornell Medicine researchers found.

The...

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Medicare Part D protected drug classes

Removing protected class regulation from Medicare prescription drug policies could greatly reduce the United States' prescription drug spending—this could have saved potentially $47 billion between 2011-2019, according to Weill Cornell Medicine researchers.

The study, published Oct. 7 in Health Affairs, aims to inform policymakers' debates about Medicare Part D covering the expense of all drugs in six "protected...

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Headshot of a male doctor wearing a suit and blue tie.

Dr. Alessandro Fichera, a prominent colorectal surgeon, has been named chief of the Division of Colorectal Surgery at NewYork-Presbyterian/Weill Cornell Medical Center and Weill Cornell Medicine, effective Oct. 14.

In his new role, Dr. Fichera leads a world-class team of colorectal surgeons that uses state-of-the-art technologies and innovative surgical techniques to provide...

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