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ribbon drawing of the CLC-ec1 transporter

Structural rearrangements allow pH-dependent activation of CLC-e1. The video depicts the molecular movements of the CLC transporter from the inactive state to its two active conformations.

The molecular workings of a family of important but hard-to-study proteins called CLCs have been illuminated as never before in a study led by researchers at Weill Cornell Medicine.

CLCs play fundamental roles in biology by regulating the levels of chloride and other ions in...

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Headshot of a woman against a gray backdrop

NEW YORK (February 13, 2023) Dr. Jennie G. Ono, a leading pediatrician who focuses on inpatient care, newborn medicine and pediatric asthma, has been appointed chief of pediatrics at NewYork-Presbyterian Queens. Dr. Ono also serves as an associate professor of clinical pediatrics at Weill Cornell Medicine.

In her new role, Dr. Ono will continue to grow the pediatric primary care, subspecialty and inpatient programs at...

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Drukier Prize event

NEW YORK (Feb. 13, 2024) — Dr. Sumit Gupta, a physician-scientist whose research focuses on vulnerable subpopulations of children with cancer, has been awarded the eighth annual Gale and Ira Drukier Prize in Children’s Health Research, Weill Cornell Medicine announced today. 

The Drukier Prize honors an early-career pediatrician whose research promises to make significant contributions toward improving the health of children and adolescents. Dr. Gupta is an associate...

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Headshot of a woman against a gray backdrop

NewYork-Presbyterian/Weill Cornell Medical Center has received the Mitral Valve Repair Reference Center Award from the American Heart Association and the Mitral Foundation for a demonstrated record of superior clinical outcomes resulting from evidence-based, guideline-directed degenerative mitral valve repair.

This award recognizes NewYork-Presbyterian/Weill Cornell Medical Center’s contribution to advancing best practices in the surgical treatment of mitral valve disease...

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lung cancer histological transformation

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment. Researchers at Weill Cornell Medicine have developed a mouse model that illuminates this problematic process, known as histological transformation. The findings advance the understanding of how mutated genes can trigger cancer evolution and suggest targets for more effective...

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A woman smiling

Video of Breast Cancer Precision Care: A Family Affair | Weill Cornell Medicine

When Nila Charles was diagnosed with breast cancer, she was the mother of two young children, working long hours and caring for a family member who was also diagnosed with cancer.

"It was a tough time, but I rallied through it," Charles recalled...

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CMV mRNA vaccine

An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate, according to a study by Weill Cornell Medicine investigators.

The study, published in the Journal of Infectious Diseases on Feb. 7, provided evidence...

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illustration of blood vessels leading to the brain

More than a decade ago, the anticoagulant apixaban, trade name Eliquis, was shown to be superior to aspirin for preventing recurrent stroke in patients with a heart condition called atrial fibrillation. But a multi-center, phase 3 clinical trial has found that apixaban is no more effective than aspirin at preventing a second stroke in patients diagnosed with a milder, related condition called atrial cardiopathy, according to results reported by researchers at Weill Cornell Medicine, Columbia...

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Dr. Alessio Accardi

Dr. Alessio Accardi, professor of physiology and biophysics in anesthesiology at Weill Cornell Medicine, has been awarded a five-year, $2.7 million grant by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health (NIH), for fundamental research on cell membrane proteins that have critical roles in biology and are involved in numerous human diseases.

The grant is a much-sought...

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Dr. Kuhn

NEW YORK (Jan. 31, 2024)—Dr. Bernhard Kühn, a leading physician-scientist who specializes in heart regeneration, has been named chief of the Division of Cardiology in the Department of Pediatrics at Weill Cornell Medicine and NewYork-Presbyterian Komansky Children’s Hospital, effective Feb. 1.

In his role as chief, Dr. Kühn will lead a skilled team of physicians and scientists committed to enhancing the division’s...

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Dr. Jeannine Gerhardt

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and the mechanisms by which they cause cell dysfunction and diseases.

The NIGMS Maximizing Investigators’ Research Award is intended to...

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photo of mosquito feeding on a human

Structural insights into a potent antimalarial drug candidate’s interaction with the malaria parasite Plasmodium falciparum have paved the way for drug-resistant malaria therapies, according to a new study by researchers at Weill Cornell Medicine and Van Andel Institute.

The antimalarial molecule, TDI-8304, is one of a new class of experimental therapeutics that targets the proteasome, an essential, multiprotein complex in P. falciparum...

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dopamine neuron senescence after COVID infection

A new study reported that SARS-CoV-2, the virus that causes COVID, can infect dopamine neurons in the brain and trigger senescence—when a cell loses the ability to grow and divide. The researchers from Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Columbia University Vagelos College of Physicians and Surgeons suggest that further research on this finding may shed light on the neurological symptoms associated with long COVID such as brain fog, lethargy and depression....

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stromal cells from prostate cancer

Non-cancerous cells called stromal cells, which are found in and around prostate tumors, may be useful in assessing these tumors’ potential to spread, and may even be targets for future prostate cancer treatments, according to a study led by researchers at Weill Cornell Medicine.

Stromal cells, found in all organs, contribute to wound-healing, blood vessel formation and structural support for tissues. Scientists know that tumors often co-opt stromal cells to create a more supportive...

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CAT scan of non small cell lung cancer

A new study reported that patients with non-small cell lung cancer (NSCLC) treated with a combination of low-dose radiation and immunotherapy had higher progression-free survival compared to patients who received immunotherapy alone two years after treatment. The findings from researchers at Weill Cornell Medicine, NewYork-Presbyterian and Columbia University Vagelos College of Physicians and Surgeons offer hope to those affected by NSCLC, the most common type of lung cancer in the United ...

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immune cells infiltrate brain after stroke

Researchers at Weill Cornell Medicine have painstakingly catalogued the cellular response to stroke in a preclinical model, identifying the immune cells involved and the roles they may play in the days and weeks following a stroke. During a stroke, loss of oxygen leads to brain damage and cell death. It also triggers a powerful inflammatory response in which the brain’s resident immune cells, along with cells recruited from the blood, infiltrate the injured tissue.


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Dr. Massimo Cristofanilli

Weill Cornell Medicine researchers received a $2.4 million grant from the U.S. Department of Defense Breast Cancer Research Program to validate a new blood test for the early detection of breast cancer.

Researchers are evaluating Syantra DX Breast Cancer (Syantra Inc.), an experimental diagnostic test that detects specific biomarkers in blood associated with breast cancer. The test uses an artificial intelligence algorithm to determine whether a patient is positive for cancer as soon...

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drawing of brain in red ink on blue background

A common type of brain bleed in older adults, known as subdural hemorrhage, is associated with the presence of amyloid deposits in cerebral blood vessels, according to a study led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and Yale School of Medicine. The study is the first to link cerebral vessel amyloid to subdural hemorrhages and should lead to a better understanding of both conditions.

For the...

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Cells labeled in pink and blue in pancreatic cancer organoid

A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic cancer treatments, according to a new study from researchers at Weill Cornell Medicine.

In the study, published Dec. 26 in Cell Stem Cell, the scientists tested more than 6,000 compounds on their pancreatic tumor organoids, which contain a common pancreatic cancer...

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tuberculosis affects the lungs

Weill Cornell Medicine researchers and the TB Drug Accelerator have received two grants totaling $6.8 million from the Bill & Melinda Gates Foundation to study tuberculosis (TB) drug development. This effort will expediate finding new drug targets within the bacteria and identifying new lead compounds, two significant bottlenecks in TB drug development.

“These grants allow us to apply the assays we’ve developed in the last few years...

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