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cytokines acting as pregnancy hormones

Researchers at Weill Cornell Medicine have discovered in a preclinical model that cytokines, proteins that control immune response, circulating in maternal blood during pregnancy may mitigate an offspring's risk for psychiatric conditions. The findings are surprising because circulating maternal cytokines are at such low levels that they were not implicated in fetal brain development and offspring behavior before.


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immunofluorescent staining of the coronary lesion

Weill Cornell Medicine investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.

In the study, published March 8 in Circulation Research, the researchers showed that boosting levels of a sphingolipid called S1P in artery-lining endothelial cells...

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illustration of bacteria floating over intestinal villi

Microbes in the mammalian gut can significantly change their hosts’ amino acid and glucose metabolism, acting almost like an extra liver, according to a new preclinical study by Weill Cornell Medicine investigators.

The study, published April 23 in Cell Host & Microbe, adds to the growing list of ways in which the microbiome influences physiology, and...

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Dr. Adam D. Cheriff

Dr. Adam D. Cheriff, a physician and healthcare executive with more than 20 years of leadership experience, has been named the new chief operating officer of Weill Cornell Medicine's Physician Organization, effective May 1. 

“I’m pleased to elevate Adam’s role within our executive leadership team.” said Dr. Robert Min, president and CEO of the Weill Cornell Medicine Physician Organization. “Adam brings both first-hand clinical knowledge and data-driven thinking about the care delivery...

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pink macrophages engulfing orange rodlike bacteria

Dr. Carl Nathan, chair of the department of microbiology and immunology and the R.A. Rees Pritchett Professor of Microbiology at Weill Cornell Medicine, has co-authored a review in Science on the immune protein interferon-gamma. He answered questions about its history and prospects as a therapeutic.

How was IFN-γ's basic biological role discovered?

In 1969-1971, while I was in medical school, I addressed a...

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WCM logo

Cornell University President Martha Pollack and Dr. Robert A. Harrington, Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, sent the following message on Apr. 22 to the Weill Cornell Medicine community.

Dear Weill Cornell Medicine Community,

This week you will likely see updates on serious allegations of misconduct against a former faculty member, which are extremely disturbing. We feel deeply for the survivors and their families. No patient who entrusts us...

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Weill Cornell Med Diversity Champions

Dr. Andrea Card, assistant professor of medicine at Weill Cornell Medicine, has always embraced diversity, equity and inclusion, starting in the 1990s when she was a medical student—long before it became a priority across the country. This year, Dr. Card received the Bruce Laine Ballard Award at Weill Cornell Medicine’s Celebration of Diversity, part of the institution’s sixth annual Diversity Week, held April 15...

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Despite decades of halting progress, women’s cardiovascular disease diagnosis, treatment and outcomes continue to lag behind men’s, said Dr. C. Noel Bairey Merz, the Irwin and Sheila Allen Chair in Women’s Heart Research in the Smidt Heart Institute at Cedars-Sinai, in her keynote address on April 16 for Weill Cornell Medicine’s sixth annual Diversity...

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Dr. LaVeist keynote

To imagine a society without racial disparities in health care, we must consider the real reasons inequities exist, said Dr. Thomas LaVeist, Dean and Weatherhead Presidential Chair in Health Equity at the Tulane University School of Public Health and Tropical Medicine, in his keynote address on April 15 for Weill Cornell Medicine’s sixth annual...

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schematic of atomic force microscopy results showing 5 states of the protein and the energy landscape

Researchers at Weill Cornell Medicine have developed a powerful, new technique to generate “movies” of changing protein structures at speeds of up to 50 frames per second.

Senior author, Dr. Simon Scheuring, the Distinguished Professor of Anesthesiology Research at Weill Cornell Medicine and colleagues developed the new approach to gain a better understanding of how biological molecules change structurally over time....

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Cinthia Garcia was always passionate about science and medicine. The first in her family to complete post-secondary education, she earned a Bachelor of Science degree at Emmanuel College in Boston in 2018 and then became a laboratory manager at the UC San Diego School of Medicine. Still, she dreamed of a career as a physician-scientist, pursuing translational research with the potential to improve patient care. 

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heart bypass surgery

Women are at higher risk of death when undergoing heart bypass surgery than men. Researchers at Weill Cornell Medicine have determined that this disparity is mediated, to a large extent, by intraoperative anemia—a decrease in red blood cell concentration during surgery. The study, published on March 5, in the Journal of the American College of Cardiology, suggests that strategies for minimizing...

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magenta and cyan stained tissue

Treatment for rheumatoid arthritis (RA) has come a long way in recent years. In many cases, a battery of medications can now successfully stymy the inflammatory cells that cause swelling and pain when they infiltrate tissues around the joints. 

Yet for some reason, about 20% of patients with painful, visibly swollen joints consistently get no relief from multiple rounds of even the strongest of these anti-inflammatory drugs.

Surgical interventions intended to remove inflamed...

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drawing of heart with ecg line emanating from it

A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms. The study, published March 25 in the Journal of the American College of Cardiology, provides real-world evidence that a wide...

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mRNA isoforms

Investigators at Weill Cornell Medicine have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, neuron specialization and other brain functions.

RNA transcripts that are copied from DNA sequences carry the instructions for building proteins and show which genes are active in a...

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image showing cells stained blue, tau aggregates in green and neuron cytoskeleton in red

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease and frontotemporal dementia. This new model has led to the identification of novel therapeutic targets that could potentially block tau spread.

The preclinical study, published April 5 in Cell, is a...

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bioengineered ear grafts

Using state-of-the-art tissue engineering techniques and a 3D printer, researchers at Weill Cornell Medicine and Cornell Engineering have assembled a replica of an adult human ear that looks and feels natural. The study, published March 16 in Acta Biomaterialia, offers the promise of grafts with well-defined anatomy and the correct biomechanical properties for those who are born with a congenital...

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cyan strands of DNA wrapped around green histone proteins

A team led by researchers at Weill Cornell Medicine has identified important drivers of the transformation of a type of blood cancer called follicular lymphoma from a slow-growing form to the aggressive form it takes in some patients.

The study, published March 7 in Cancer Cell, showed that while mutations affecting a gene-regulating complex called BAF can put the cancer on a dangerous trajectory, they also...

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Dr. Jedd Wolchok

A collaboration between Dr. Jedd Wolchok, the Meyer Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, and Dr. Yelena Janjigian, chief of the gastrointestinal oncology service at Memorial Sloan Kettering Cancer Center, is looking to transform the care of gastroesophageal cancer (GEC)...

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lung fibrosis

Researchers at Weill Cornell Medicine have discovered a protein that plays a critical role in clearing collagen from tissue and may be a therapeutic target to help prevent fibrosis, scar tissue that interferes with organ function. The paper, published on Feb. 20 in Nature Communications, provides clues that could lead to drug development for diseases like lung fibrosis which have no drug options currently.


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