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image of human sperm from video showing effects of male contraceptive drug candidate

Video of sAC Inhibitor Blocks Sperm Motility

This video shows the motility of human sperm in the absence (left, vehicle control) or presence (right, sAC inhibitor) of the experimental male contraceptive drug candidate. Credit: Dr. Melanie Balbach

An experimental contraceptive drug candidate developed by Weill Cornell Medicine investigators temporarily stops sperm in their tracks and...

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3d illustration of cancer cells

Five teams led by Weill Cornell Medicine scientists have been awarded funding from the Starr Cancer Consortium in its 16th annual grant competition. The grants will fund research on the molecular origins and evolution of blood, bladder, breast, and colon cancers.

The Starr Cancer Consortium was established in 2006 through the philanthropy of the Starr Foundation, and includes...

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Radiologist examining a chest X-ray of a patient.

Surgery that removes only a portion of one of the five lobes that comprise a lung is as effective as the traditional surgery that removes an entire lobe for certain patients with early-stage lung cancer, according to results of a phase 3 multicenter clinical trial sponsored by the Alliance for Clinical Trials in Oncology, an NCI-supported clinical trials network. The trial team was led by Dr. Nasser Altorki, chief of the Division of...

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mRNA illustration

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine. The finding solves a 50-year mystery concerning the purpose of these chemical modifications and suggests that faulty mRNA modification may underlie some autoimmune and inflammatory disorders.

The researchers, whose findings appear Feb. 1 in Nature, discovered...

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Stock image of the Brooklyn Bridge

Dr. Asad Siddiqi, a leading rehabilitation medicine physician who specializes in the comprehensive management of acute and chronic sports injuries, has been named chief of the Department of Physical Medicine and Rehabilitation at NewYork-Presbyterian Brooklyn Methodist Hospital. Dr. Siddiqi is also an assistant professor of clinical rehabilitation medicine at Weill Cornell Medicine and adjunct...

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Interim Dean Dr. Francis Lee sent the following message Jan. 26 to the Weill Cornell Medicine community.

Dear Colleagues,

After much consideration, I am reaching out to inform you that Weill Cornell Medicine will no longer submit data to U.S. News & World Report (USNWR) for its medical school rankings.

While medical schools share many common goals, we also have unique institutional cultures and missions, as well as different pedagogical approaches and...

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illustration of double helix and chromosomes

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan. 5 in Molecular Cell, solves a mystery that has long puzzled biologists.

The cells of humans and all other higher organisms use a complex system of checkpoints and “licensing” proteins to...

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Illustration of a B cell and antibodies

The key to understanding how the most aggressive lymphomas arise and resist current therapies may lie in mutations that disrupt a critical natural selection process among antibody-producing B cells, according to a multi-institutional preclinical study led by Weill Cornell Medicine investigators.

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, with at least 40 percent of cases not responding to treatment. Patients with mutations in the B-cell...

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illustration of cells

A protein commonly found at high levels in lung cancer cells controls a major immunosuppressive pathway that allows lung tumors to evade immune attack, according to a study led by researchers at Weill Cornell Medicine. The discovery could hasten the development of treatments that overcome this tumor defense mechanism and improve outcomes for lung cancer patients.

In the study, which appears Jan. 9 in Nature Communications...

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an elder man looking out a window deep in thought

The National Institute on Aging of the National Institutes of Health has awarded a grant to Weill Cornell Medicine to develop a screening tool and intervention for elder neglect in patients with Alzheimer’s disease and related dementias.

Approximately one in 10 Americans over the age of 60 have experienced some form of elder abuse, a broad category that encompasses financial exploitation, physical abuse, emotional abuse, neglect and more. For this study,...

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A person lighting a cigarette

Cigarette smoking is associated with worse cognitive performance among people 60 years and older, and that association is broadly the same whether or not individuals have hypertension or diabetes, according to a study from investigators at Weill Cornell Medicine and NewYork-Presbyterian. The findings, published Dec. 6 in the Journal of Alzheimer’s Disease, underscore smoking’s adverse effect on...

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students posing together to take a picture

More than 160 faculty and students filled Uris Auditorium Dec. 5 to hear doctoral candidates deliver bite-size presentations of their research in an entertaining way. The catch? They had to deliver their work in three minutes or less.

Oftentimes, the theses presentations were full of puns and good humor. From likening the ability of the blood-brain barrier to block the easy passage of molecules to a strict bouncer standing imposingly at a party’s entrance, and depicting a RAS mutant...

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microscopic image

A new method can illuminate the identities and activities of cells throughout an organ or a tumor at unprecedented resolution, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and the New York Genome Center.

The method, described Jan. 2 in a paper in Nature Biotechnology, records gene activity patterns and the presence of key proteins in cells across tissue samples, while...

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trophy illustration

Dr. Duncan Hau, assistant professor of clinical pediatrics, has been elected to the Association of Pediatric Program Directors Global Health Learning Community Steering Committee. Committee members...

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illustration of a microscopic image

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine. The finding suggests that the enzyme may be a potential target for future cancer treatments.

In the new...

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The post-COVID syndrome known as long COVID has four major subtypes defined by different clusters of symptoms, according to a study led by researchers at Weill Cornell Medicine.

The study, published Dec. 1 in Nature Medicine, was the largest of its kind to examine long COVID. The researchers, who represent clinicians and informaticists, used a machine-learning algorithm to spot symptom patterns in the health...

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microscopic embryo images

An artificial intelligence algorithm can determine non-invasively, with about 70 percent accuracy, if an in vitro fertilized embryo has a normal or abnormal number of chromosomes, according to a new study from researchers at Weill Cornell Medicine.

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a pregnant individual getting a check up

Individuals who were already pregnant at the beginning of the COVID-19 pandemic had a 50 percent lower exposure to SARS-CoV-2 compared with those who became pregnant after the pandemic began and the general population, according to a new model created by Weill Cornell Medicine, NewYork-Presbyterian and University of Oxford investigators.

The findings, published Oct. 30 in the journal Viruses, are some of the most extensive data to...

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microscopic image

An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models, according to a new study by Weill Cornell Medicine investigators.

Mesenchymal colorectal cancer (mCRC) accounts for about one-third of all colorectal cancers. Targeted immune therapies aren't effective against this form of cancer because the environment inside the tumor keeps immune cells that would kill the tumor cells at bay. But a team led by...

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a male doctor giving a vaccine to a pregnant woman

The long-term immune response to SARS-CoV-2 mRNA vaccination was similar in pregnant individuals compared with non-pregnant individuals of reproductive age, according to a study by investigators at Weill Cornell Medicine and NewYork-Presbyterian. The similarity in protection is noteworthy, given that pregnancy alters the immune system, and potentially the response to vaccination.

The findings, published Nov. 2 in the...

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