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transcription factor and DNA

Researchers at Weill Cornell Medicine have used artificial intelligence to identify drug targets based on mapping regulatory networks in patient tumors. The study, published Sept. 4 in Cell Systems, experimentally identified and validated four drug candidates for neuroendocrine, liver and renal cancers, which have a dismal prognosis with current therapeutic options.

This research offers a much-needed new way...

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telehealth mother child

In a first-of-its-kind study, Weill Cornell Medicine researchers found that female physicians, primary care physicians, psychiatrists and physicians in non-rural areas delivered relatively higher proportions of visits via telehealth. This national analysis may provide key information for policymakers to consider as COVID-19 provisions for expanded Medicare telehealth coverage are set to expire at the end of this year.

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Liston Salience Network

By repeatedly scanning the brains of a small group of patients for a year and a half, Weill Cornell Medicine researchers have identified a distinct pattern of neuronal interactions that appears to predispose some people to developing depression.

Published Sept. 4 in Nature, the work highlights the potential of a new “deep scanning” approach to help predict a person’s...

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HIV virus particles

Research at Weill Cornell Medicine suggests that childhood immunization against HIV could one day provide protection before risk of contracting this potentially fatal infection dramatically increases in adolescence.   

The study, published Aug. 30 in Science Immunology, demonstrated that a series of six vaccinations containing a modified protein from the surface of HIV particles stimulated initial steps of a potent...

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H&E histology slides and immunofluorescent images of B cells and T cells

A machine-learning tool created by Weill Cornell Medicine and Hospital for Special Surgery (HSS) investigators can help distinguish subtypes of rheumatoid arthritis (RA), which may help scientists find ways to improve care for the complex condition.

The study published Aug. 29 in Nature Communications shows that artificial intelligence and machine learning technologies can effectively and efficiently subtype...

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immunofluorescence image of a hippocampal neuron stained for PGK1

An enzyme called PGK1 has an unexpectedly critical role in the production of chemical energy in brain cells, according to a preclinical study led by researchers at Weill Cornell Medicine. The investigators found that boosting its activity may help the brain resist the energy deficits that can lead to Parkinson’s disease.

The study, published Aug. 21 in Science Advances, presented evidence that PGK1 is a “rate-limiting”...

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Maya app for depression

Researchers at Weill Cornell Medicine and NewYork-Presbyterian found that a self-guided cognitive behavioral therapy (CBT) app, called Maya, significantly reduced anxiety in young adults struggling with mental health challenges. The decrease in anxiety symptoms was clinically and statistically significant at six weeks and continued at the 12-week follow-up period with improvement levels similar to anxiety medication studies.

The...

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drawing of DNA next to a sand timer

Researchers at Weill Cornell Medicine and the epigenetics company TruDiagnostic have uncovered DNA markers in our genes associated with retroelements, remnants of ancient viral genetic material, that may be involved in aging. The results support the idea that certain retroelements in the human genome may act as highly accurate epigenetic clocks able to predict chronological age.

Retroelements have been known to impact gene regulation, gene expression, genomic stability and the...

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illustration of the cell nucleus in the interphase (DNA, mRNA, nucleolus and several enzymes)

Weill Cornell Medicine has received a five-year, $12.4 million grant from the National Cancer Institute, part of the National Institutes of Health, for an extensive program of basic and translational research on the biology of diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma.

The investigator-initiated Program Project grant, led by Dr. Leandro Cerchietti, the Richard A. Stratton Associate Professor in...

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fMRI images of control patients and a patient with cognitive-motor dissociation

With surprising frequency, patients with severe brain injury can show clear signs of cognitive function on brain scans in response to requests to carry out complex mental work, even when they can’t move or speak, according to an international study co-led by Weill Cornell Medicine and NewYork-Presbyterian investigators.

The study, published Aug. 14 in the New England Journal of Medicine, was the largest-ever...

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Medical students in white coats sitting in an auditorium.

Video of Class of 2028 White Coat Ceremony Highlights | Weill Cornell Medicine

Anisah Alladeen’s path to joining Weill Cornell Medical College’s Class of 2028 was almost 10 years in the making. 

Growing up in a Guyanese household in Queens, Alladeen witnessed firsthand the challenges immigrant communities face navigating the health care system. She often found herself encouraging her family and...

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Medicaid enrollees difficulty in finding care

Many people enrolled in Medicaid who require psychiatric care have difficulty accessing clinicians in a timely manner despite the higher need in this population, according to a study by researchers at Weill Cornell Medicine.

The ...

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image of neurons with EEG trace and chemical structure superimposed on them

The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a study led by researchers at Weill Cornell Medicine and Linköping University in Sweden.

In their study, published July 31 in Nature, the researchers determined the high-resolution structural details of how propofol inhibits the activity of HCN1, an ion channel protein found...

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illustration of a heart with an EKG reading next to it

A dual-chamber wireless pacemaker provides reliable performance over three months, bolstering evidence for this new pacemaker option, according to results from a multi-center, international clinical trial co-led by a Weill Cornell Medicine and NewYork-Presbyterian investigator.

The results, published July 8 in Circulation, showed that the two tiny pieces of this wireless pacemaker system reliably...

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image of immune cells, stained brown, and ovarian cancer cells with various treatments

An iron-binding drug that is already approved for treatment of other diseases could provide a novel way to attack ovarian tumors, according to a new study led by Weill Cornell Medicine researchers. The preclinical study, which combined the analysis of human ovarian tumors and animal models of the disease, was published on...

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abstract image of pen and stethoscope

Two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients, according to a new study by investigators at Weill Cornell Medicine, the University of Pennsylvania, and Medidata AI. Black and Hispanic patients are historically underrepresented in cancer clinical trials; equitable enrollment helps ensure the knowledge...

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multiple myeloma cells

A simple blood test that measures the number of lymphocytes, a type of white blood cell in the body, may predict whether people who have relapsed multiple myeloma are going to respond well to CAR-T immunotherapy, according to new research from Weill Cornell Medicine, NewYork-Presbyterian, Columbia University and Icahn School of Medicine at Mount Sinai.

The...

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Lewy-body like inclusion in mutant mouse retina

A new preclinical model offers a unique platform for studying the Parkinson’s disease process and suggests a relatively easy method for detecting the disease in people, according to a study led by Weill Cornell Medicine researchers.

In the study, published July 23 in Nature Communications, the researchers showed that knocking out a key component involved in protein transportation in the light-sensing rod cells of mice...

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Dr. Brad Jones

Weill Cornell Medicine has received $4.2 million to study how the immune system in some people infected with HIV can keep the virus under control, which could lead to novel therapeutic strategies for thwarting or eliminating HIV. Dr. Brad Jones, associate professor of immunology in medicine in the Division of Infectious Diseases at Weill...

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concept illustration of circuits and brain

Researchers at Weill Cornell Medicine have used machine learning to define three subtypes of Parkinson’s disease based on the pace at which the disease progresses. In addition to having the potential to become an important diagnostic and prognostic tool, these subtypes are marked by distinct driver genes. If validated, these markers could also suggest ways the subtypes can be targeted with new and existing drugs.

The ...

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