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an image of a heart with a beat strike

A simple surgical technique during cardiac surgery was associated with a 56 percent reduction in the incidence of an irregular heart rhythm known as atrial fibrillation that can lead to stroke, with no added risks or side effects, according to a new study by Weill Cornell Medicine and NewYork-Presbyterian investigators. The findings suggest that the method, called posterior left pericardiotomy, has significant potential for preventing prolonged hospital stays and the need for additional...

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a bunch of pills scattered on a table

Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The results illuminate one of the central problems of drug discovery and point to new strategies for solving it.

Any class of drug can have side effects, but those that interact directly with cellular membranes have been especially problematic. "Those drugs tend to affect many membrane proteins,...

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brain illustration

Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial from investigators at Weill Cornell Medicine and Angel H. Roffo Cancer Institute.

The study, published Nov. 5 in Science Advances, reported the results of administering arginine, which can be delivered in oral...

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A group of people together

Collaborating with traditional healers to deliver point-of-care HIV tests to individuals in rural Uganda quadrupled testing rates compared with standard referrals to HIV clinics, according to a trial by Weill Cornell Medicine and Mbarara University of Science and Technology investigators. The healer-delivered HIV testing model has the potential to significantly improve the uptake of HIV testing among hard-to-reach populations in HIV-endemic regions of sub-Saharan Africa, as well as improve...

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B-cell lymphoma

Lymphomas can turbo-charge their ability to proliferate by crowding growth-supporting enzymes into highly concentrated compartments within tumor cells, according to a study led by researchers at Weill Cornell Medicine.

The preclinical study, published Sept. 3 in Cancer Research, demonstrated that certain aggressive B-cell lymphomas use a protein-shepherding molecule called HSP90 to form and...

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a lychee martini

A brain circuit that works as a “brake” on binge alcohol drinking may help explain male-female differences in vulnerability to alcohol use disorders, according to a preclinical study led by scientists at Weill Cornell Medicine.

In the study, which appeared Aug. 23 in Nature Communications, the researchers examined a brain region in mice called the bed nucleus of the stria terminalis (BNST)—a major node in a...

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illustration of a brain tumor

A team led by researchers at Weill Cornell Medicine, the New York Genome Center, Harvard Medical SchoolMassachusetts General Hospital and the Broad Institute of MIT and Harvard has profiled in unprecedented detail thousands of individual cells sampled from patients’ brain tumors. The findings, along with the methods...

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coronavirus illustration

Convalescent plasma did not reduce the risk of intubation or death for hospitalized COVID-19 patients in a large, international clinical trial conducted by Weill Cornell Medicine and NewYork-Presbyterian investigators in collaboration with lead investigators at McMaster University.

The study, published Sept. 9 in Nature Medicine, also revealed that patients who received convalescent plasma experienced...

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white b cell among red blood cells

The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system and may help understand how tissues develop and how certain cancers arise.

The study, published Sept. 23 in Nature Immunology, combined computational analyses with advanced molecular biology and...

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microscopic image

Turning off a defense mechanism that protects colorectal cancer tumors from being discovered by immune cells could be a possible strategy for treating the disease, according to a new study by Weill Cornell Medicine investigators. Because immunotherapy reactivates immune cells near a tumor, but fails when those cells aren’t present in significant numbers, the new approach could potentially complement this type of treatment or work on its own.


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microscopic image

Malignant tumors can enhance their ability to survive and spread by suppressing antitumor immune cells in their vicinity, but a study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian has uncovered a new way to counter this immunosuppressive effect.

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image of an ambulance

Stroke patients received clot-busting medication more quickly,and had better recoveries, when treated by an ambulance-basedmobile stroke unit (MSU) compared with standard emergency room (EMS) care, according to a study from researchers at UTHealth Houston, Memorial Hermann-Texas Medical Center, Weill Cornell Medicine, NewYork-Presbyterian, and five other medical centers across the United States.

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image of DNA wrapped around protein complex

A team co-led by scientists at Weill Cornell Medicine has revealed in detail how the most common primary eye cancer in adults, uveal melanoma (UM), can progress from a slow-growing, “indolent” state to a lethal metastasizing state. The discovery is a significant advance in fundamental cancer research that also suggests new strategies for treatment.

The scientists, whose study is published Sept. 13 in Nature Communications...

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an illustration of tuberculosis

Tuberculosis (TB) is a wily old killer, one of the deadliest infectious diseases in history and one of the few that naturally infects only humans. Researchers at Weill Cornell Medicine have been pursuing treatments for tuberculosis caused by Mycobacterium tuberculosis (Mtb) since the 1950s, and the program continues to excel at explaining TB’s mysteries and pushing toward more effective therapies.

Currently, Weill Cornell Medicine investigators are...

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baby on a hospital bed

Children with infantile spasms, a rare form of epileptic seizures, should be treated with one of three recommended therapies and the use of non-standard therapies should be strongly discouraged, according to a study of their effectiveness by a Weill Cornell Medicine and NewYork-Presbyterian investigator and collaborating colleagues in the Pediatric Epilepsy Research Consortium. Early treatment with an effective therapy is important for improving neurodevelopmental outcomes and, for some...

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Group photo from Class of 2025 White Coat ceremony

Video of Class of 2025 White Coat Ceremony Highlights | Weill Cornell Medicine

As a child, Noelle Desir, 23, suffered from severe eczema. She and her family tried everything to bring the skin condition under control, but without insurance, all they could do was visit the emergency room when she had a flare-up. Finally at age 12, her father, an immigrant from Haiti, secured...

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painting showing the inside of a colon with bacteria and tumor cells

An immune cell subset called innate lymphoid cells (ILC3s) protects against colorectal cancer, in part by helping to maintain a healthy dialogue between the immune system and gut microbes, according to a new study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian. The finding opens the door to new strategies for treating this type of cancer.

The researchers, who published their findings August 17...

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diagram of microscope tip and ion channel in membrane

Researchers at Weill Cornell Medicine have shown that they can record the high-speed motions of proteins while correlating their motion to function. The feat should allow scientists to study proteins in greater detail than ever before, and in principle enables the development of drugs that work better by hitting their protein targets much more effectively.

The researchers, in a study published July 16 in Nature...

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figures under a microscope

The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a study led by researchers at Weill Cornell Medicine. The discovery could lead to new methods for classifying and treating patients with this disease.

The researchers, who published their findings August 11 in Cell, found that in a number of lupus patients, maturing red blood cells fail to...

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Dr. Geraldine McGinty

Dr. Geraldine McGinty, an esteemed clinical operations strategist, administrator and radiologist, has been appointed senior associate dean for clinical affairs at Weill Cornell Medicine, effective Sept. 1.

In her new role, Dr. McGinty will provide Dean Augustine M.K. Choi with strategic counsel and work to realize his vision for the institution’s clinical...

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