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brain showing flurorescent prefrontal cortex cells

To enable animals to shift their attention in response to changing circumstances, the prefrontal cortex of the brain helps keep track of which types of stimuli have recently been most relevant, suggests a preclinical study by Weill Cornell Medicine and NewYork-Presbyterian investigators. This discovery could lead to new treatments to help restore cognitive flexibility.

“Animals and people make split-second decisions about what to do in changing circumstances and what to pay attention...

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T cell lymphocyte with receptors

Radiation therapy appears to increase or upregulate the expression of genes with mutations that induce an immune response to malignant cells, according to preclinical research by Weill Cornell Medicine and NewYork-Presbyterian investigators. The findings suggest that radiation treatment directed to tumors may help to improve a form of immunotherapy that currently has limited effectiveness.

The new research, published Jan. 21 in The...

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cells under a microscope

Molecular "bookmarks," which allow cells to retain their characteristics during cell division, ensure fast reactivation of critical cell identity genes after cell division, according to investigators at Weill Cornell Medicine. The new work helps illuminate a process that has puzzled biologists for decades and suggests new strategies for modulating cell fate both for stem cell therapy and cancer treatment.

When cells undergo division, or mitosis, they temporarily shut down their normal...

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a woman smiling for a photo, holding a sign showing where she matched for Match Day 2021

Video of A Virtual Celebration for Match Day 2021 at Weill Cornell Medicine

For Rana Khan, earning a residency in obstetrics and gynecology at NewYork-Presbyterian/Weill Cornell Medical Center was more than just realizing a milestone in her medical education. Match Day was the culmination of a personal journey that transported Khan from medical student to cancer patient to...

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an illustraion of a heart graph made out of sugar

Excess sugar in the blood, the central feature of diabetes, can react with immune proteins to cause myriad changes in the immune system, including inflammatory changes that promote atherosclerosis, according to a new study from scientists at Weill Cornell Medicine and University of Massachusetts Medical School.

The study, published March 15 in the journal Immunity, advances the field of diabetes research by...

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illustration of cells in the body

A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain.

Isoform variation is a process that extends the versatility of...

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Composite photo of two scientists

The first and largest genetic association study in the Middle East revealed genetic variations that are specific to the Qatari population, a group of researchers at Qatar Foundation reported Feb. 23 in Nature Communications.

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cells under a microscope

A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators.

Studies of humans who live longer than 100 years have shown that many share an unusual version of a gene called Forkhead box protein O3 (FOXO3). That discovery led...

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a man putting on two masks

With the recent spread of new coronavirus variants, some people have begun wearing two masks at the same time — double masking. On February 10, the Centers for Disease Control and Prevention (CDC) released new guidance that confirmed that wearing well-fitted masks or...

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Illustration of brain neurons

Five Weill Cornell Medicine investigators have received funding from the Chan Zuckerberg Initiative (CZI) for their research in inflammation and neurodegenerative disorders.

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colon tumor in mice

Molecular changes in cells called fibroblasts, which help provide support for...

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Activation of the ERK pathway is visualized in red in the femur of mice lacking MEKK2. Cell nuclei are stained in blue, and where the stains overlap, the image appears to be pink.

Common...

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Dr. Roy Gulick leaning on desk in office

Weill Cornell Medicine has received a renewal of a prestigious ...

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Molecular model of pembrolizumab, an antibody used in immunotherapy for cancer.

The immunotherapy drug pembrolizumab, known by its brand name Keytruda, is a safe and effective option for patients with locally advanced...

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Representation of metastatic bladder cancer as an anatomical organ with malignant cells spreading in the human body.

A significant percentage of patients with urothelial cancers have inherited gene variants that...

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Histone H1 binds and condenses DNA to repress gene activity. Mutations in histone H1 have been identified at high frequency in many hematological malignancies.

...

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Headshot of Dr. Ronald Crystal in lab coat

A gene therapy developed by Weill Cornell Medicine and NewYork-Presbyterian investigators helped slow progression of a rare and fatal genetic disorder in children called late infantile Batten...

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Microscopic image of Ustilago maydis cells, the image shows that damaged telomeres can recruit a DNA repair protein.

Researchers at Weill Cornell Medicine have...

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female physician talking to male patient

Patient mistrust of the healthcare system, which has come under new focus during the COVID-19 pandemic, is partly the result of an increasingly consumer-oriented healthcare system, according to a new commentary by a Weill Cornell Medicine investigator.

"Trust is the glue that holds all of healthcare together,” said lead author Dr. Dhruv Khullar, an assistant...

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